Effect Evaluation of Transfat Decoction on Obesity Mice Induced by High-Fat Diet

Author Info

Qianyi Zhou Jianming Ma Zejia Zhang Ziqian Wang

Corresponding Author

Jianming Ma
College of Traditional Chinese Medicine, Hebei University, Baoding, 071000, Hebei province, China

A B S T R A C T

Objective: To investigate the effect of Tranfat Decoction on obesity mice induced by high-fat diet. Methods: 90 healthy SPF C57BL/6 male mice aged 3 weeks were selected and 15 of them were treated as normal group. The remaining 75 mice were used as model group to induce obesity. After successful modeling, drug intervention was given for 6 weeks, and body weight, body fat content and blood fat level of the mice were measured. Results: After 6 weeks of drug intervention, compared with the model blank group, the body weight of the drug administration group all decreased to different degrees (P < 0.05). TC, TG, LDL-C and HDL-C levels were significantly different in the high-dose group (P < 0.05). Fat volume was lower in the administration group (P < 0.05). Conclusion: Tranfat Decoction can reduce body weight, body fat content and blood fat level in obese mice induced by high-fat diet.

Article Info

Article Type

Research Article

Publication history

Received: Fri 29, Mar 2019
Accepted: Mon 15, Apr 2019
Published: Mon 22, Apr 2019

Copyright

© 2023 Jianming Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JFNM.2019.01.01