Effects of Cannabis Oil on Cannabinoid-Induced Tetrad, Blood Pressure, and Metabolic Parameters in an Experimental Model of Metabolic Syndrome

Effects of Cannabis Oil on Cannabinoid-Induced Tetrad, Blood Pressure, and Metabolic Parameters in an Experimental Model of Metabolic Syndrome

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for researchers?

Comments: The title, "Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome," indicates that the topic is relevant to the Journal of Food Nutrition and Metabolism's area of interest. The study investigates the effects of cannabis oil, which is derived from a plant-based source, on metabolic parameters and blood pressure in an experimental model. This aligns with the journal's focus on food, nutrition, and metabolism.

 

The topic is contemporary and interesting for researchers as it explores the potential therapeutic effects of cannabis oil on Metabolic Syndrome, a prevalent condition with significant health implications. The research also contributes to the ongoing investigation of the effects of cannabinoids on various health conditions, which is a topic of growing interest in the scientific community.

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

Comments: Yes, the abstract includes all the required components: objective, methods, results, and conclusions. The abstract provides a clear overview of the study, its methodology, and the outcomes. The keywords chosen are appropriate as they cover the main topics discussed in the article.

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

Comments: The goal of the article is explicitly stated in the introduction: "In this study, we investigate the effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters present in experimental Metabolic Syndrome induced by SRD-fed rats."
The goal is clear and unambiguous, as it outlines the primary aim of the research, which is to investigate the effects of cannabis oil on specific parameters in rats with Metabolic Syndrome.

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

Comments: The paper's structure appears coherent and is in coherence with the goal of the paper. The article is organized into sections that follow a logical sequence, including introduction, materials and methods, results, and discussion. The introduction provides background information on metabolic syndrome (MS) and the potential role of cannabinoids in its treatment. The materials and methods section describes the experimental design, including the preparation of cannabis oil, animal models, diets, and analytical methods. The results section presents the findings of the study in a clear and organized manner, with supporting figures and tables. Finally, the discussion section interprets the results and relates them to the existing literature, suggesting possible mechanisms and implications for future research.

 

Overall, the paper's structure supports its goal of investigating the effects of cannabis oil on blood pressure and metabolic parameters in an experimental model of metabolic syndrome induced by sucrose-rich diets in rats.

 

Tools and Methods

Q: Are methods the author uses adequate and well used?

Comments: The methods described in the article appear to be adequate and well-used, as they cover various aspects of the study and are based on established techniques. The author provides detailed information on the preparation and characterization of cannabis oil, the animal subjects, diets, experimental setup, and various tests and measurements. The article also includes a statistical analysis section that employs appropriate tests for data comparison and significance determination.

Overall, the methods described in the article are well-structured, clear, and based on established techniques, making them adequate and well-used for the study.

 

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

Comments: The article discusses a study that found the administration of cannabis oil rich in CBD-THC (2:1) resulted in significant improvements in several parameters related to multiple sclerosis (MS). The study observed that cannabis oil did not affect body weight, food intake, and liver weight. The cannabis oil also decreased systolic and diastolic blood pressure in dyslipidemic and hypertensive rats fed with a sucrose-rich diet (SRD). Additionally, the administration of cannabis oil significantly increased analgesia in rats and improved serum triglyceride, cholesterol, and uric acid levels with no change in glucose levels. The results suggest that cannabis oil may have beneficial effects in treating hypertension, dyslipidemia, and liver damage, which are all parameters included in MS. However, further research is needed to fully understand the mechanisms behind these phenomena.

 

Literature

Q: Does the author utilize relevant literature?

Comments: Yes, the author of the article utilizes relevant literature by citing numerous studies and research papers to support their arguments and findings. They mention both animal and clinical studies and refer to various cannabinoids and their effects on different parameters.

 

Author's knowledge

Q: What is the level of author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

Comments: It is difficult to assess the author's level of knowledge without knowing their background or qualifications. However, the article does appear to reference a variety of recent studies relevant to the topic, indicating the author has some understanding of the subject matter.


Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

Comments: The length of this article appears adequate for the significance of the topic. It provides a detailed account of the study conducted, materials and methods used, and the results and discussion of the findings. Shortening the paper may result in the loss of valuable information and could potentially decrease its value.

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Yes, the legends are clear.

 

Writing style

Q: Is it clear and understandable?

A: Yes, it is understandable.

 

Further comments on the paper

Comments:

This article investigates the effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in experimental Metabolic Syndrome induced by sucrose-rich diet-fed rats. The study is the first to examine the metabolic effects of oral administration of cannabis oil with a CBD:THC ratio of 2:1 in this context.

 

The authors found that cannabis oil treatment did not affect body weight, food intake, or liver weight, but it did result in significant improvement in various parameters of Metabolic Syndrome. Cannabis oil decreased systolic and diastolic blood pressure in dyslipidemic and hypertensive rats fed with a sucrose-rich diet. The treatment also significantly decreased serum triglyceride and cholesterol levels, reaching reference values, and reduced uric acid levels. Additionally, cannabis oil significantly increased analgesia and decreased locomotion in the SRD+Ca group.

 

In summary, the study provides valuable insights into the potential therapeutic effects of cannabis oil on Metabolic Syndrome, indicating that it may offer benefits in terms of blood pressure and metabolic parameters. However, further research is needed to confirm these findings and to explore the potential of cannabinoids in the management of Metabolic Syndrome and related conditions.

 

Q: Would you recommend this manuscript for further publication?

A: Yes- Suitable to be published

If you have any questions and clarifications you can write to the journal.

Thanks,
Science Repository Team

 

 
 

Author Info

Corresponding Author
María Eugenia D’Alessandro
Laboratorio de Estudio de Enfermedades Metabólicas relacionadas con la Nutrición. Facultad de Bioquímica y Ciencias Biológicas. Universidad Nacional del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina

Article Info

Article Type
Research Article
Publication history
Received: Thu 09, Mar 2023
Accepted: Tue 04, Apr 2023
Published: Mon 17, Apr 2023
Copyright
© 2023 María Eugenia D’Alessandro. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JFNM.2023.01.01