Concomitant Thrombotic Microangiopathy and Rejection in a Recent Kidney Transplant: A Case Study

Concomitant Thrombotic Microangiopathy and Rejection in a Recent Kidney Transplant: A Case Study

Author Info

Corresponding Author
Muhammad A. Bukhari
Taif University, College of Medicine, Saudi Arabia


Thrombotic microangiopathy (TMA) is an uncommon, life-threatening complication that adversely affects kidney transplant recipient and allograft survival. Post-transplantation TMA can occur as recurrence of the primary TMA or as a de novo condition. The latter can be triggered by numerous factors post-transplantation including calcineurin inhibitors, certain infections and antibody-mediated rejection. Rejection-associated TMAs carry a significantly lower graft survival rate compared with post-transplant TMAs that are not associated with rejection. In this case report, we present a rare case of rejection-associated TMA in a recently transplanted renal allograft that was managed in Al-Hada Armed Forces Hospital. Despite the poor expected outcome of this condition; the patient was successfully treated after early initiation of medical interventions. Transplantation teams may face many challenges managing such a combination of medical conditions, which may halt pursuing appropriate diagnostic and therapeutic measures in a timely fashion. This article highlights some of these challenges for better understanding of such a complex condition.

Article Info

Article Type
Case Study
Publication history
Received: Mon 13, Jan 2020
Accepted: Mon 27, Jan 2020
Published: Fri 31, Jan 2020
© 2021 Muhammad A. Bukhari. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.
DOI: 10.31487/j.TCR.2020.01.01