Effects of Cannabis Oil on Cannabinoid-Induced Tetrad, Blood Pressure, and Metabolic Parameters in an Experimental Model of Metabolic Syndrome

Effects of Cannabis Oil on Cannabinoid-Induced Tetrad, Blood Pressure, and Metabolic Parameters in an Experimental Model of Metabolic Syndrome

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María Eugenia D’Alessandro
Laboratorio de Estudio de Enfermedades Metabólicas relacionadas con la Nutrición. Facultad de Bioquímica y Ciencias Biológicas. Universidad Nacional del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina


Objective: The aim of the present study was to analyse the effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in rats normal fed a sucrose-rich diet (SRD). Methods: Male Wistar rats were fed the following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD and SRD+Cannabis oil (SRD+Ca): the oral administration of 1 mg/kg of body weight of cannabis oil daily. Cannabis oil present a total cannabinoids CBD:THC 2:1 ratio. During the experimental period, body weight, food intake, blood pressure, body temperature, locomotion, catalepsy and analgesia were evaluated. At the end of the experimental period, levels of glucose, triglycerides, cholesterol, uric acid, AST, ALT and AP in serum were evaluated. In liver were determined AST, ALT and AP enzymes and triglycerides and cholesterol content. Results: A cannabis oil administration significantly increased (P<0.05) analgesia, and locomotion was also significantly decreased, which was found to be increased in the SRD group. Systolic and diastolic blood pressure decreased during the experiment. In the SRD+Ca group, serum triglycerides and cholesterol levels significantly decreased, reaching values similar to RD group, without changes in glucose levels. In addition, serum uric acid and AP levels significantly decreased, although did not obtain reference values. AST and ALT levels in serum and liver significantly decreased, reaching reference values. At the liver, the triglycerides and cholesterol content significantly decreased with the administration of cannabis oil, although not reaching to reference values. Conclusions: Our results suggest that cannabis oil could be useful as a therapeutic strategy to prevent some of the alterations present in Metabolic Syndrome, including hypertension, dyslipidemia and liver damage. In addition, the analgesic effect of cannabis oil could be observed in SRD-fed rats.

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Article Type
Research Article
Publication history
Received: Thu 09, Mar 2023
Accepted: Tue 04, Apr 2023
Published: Mon 17, Apr 2023
© 2023 María Eugenia D’Alessandro. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JFNM.2023.01.01