A Long-Term and Sustainable Response to Orapali in a BRCA2 Mutant Advanced Pancreatic Cancer: A Case Report

A Long-Term and Sustainable Response to Orapali in a BRCA2 Mutant Advanced Pancreatic Cancer: A Case Report

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for researchers?

Comments: Yes, the topic is relevant to the journal area of interest.

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

Comments: Yes, the abstract of the case report includes the required components that are typically found in scientific abstracts. It provides a concise overview of the case, including the patient's condition, treatment approach, and outcomes.

Regarding the keywords, the chosen keywords are relevant to the content of the case report and capture its main focus. "Pancreatic cancer," "BRCA2 mutant," and "PARP inhibitors" are appropriate keywords that reflect the key aspects of the case. These keywords would help researchers and readers to easily find and understand the main theme of the study when searching for related literature.


Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

Comments: The paper's structure is mostly coherent and follows a logical flow. It begins with an abstract that provides a concise summary of the case report, highlighting the key aspects of the patient's condition, treatment, and outcomes. The abstract is well-organized and serves its purpose of quickly conveying the main findings of the case report.


The introduction provides relevant background information about pancreatic cancer, its challenges, and the role of PARP inhibitors and BRCA mutations.

Tools and Methods

Q: Are methods the author uses adequate and well used?

Comments: The methods used in the case report are well-suited to describe the patient's diagnosis, treatment regimen, and clinical outcomes. The utilization of immunohistochemistry, NGS, standard chemotherapy, and targeted therapy (PARP inhibitors) align with current practices in oncology and genetic analysis.

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

Comments: The discussion and conclusion sections of the case report are related to the results presented earlier.


Q: Does the author utilize relevant literature?

Comments: Yes, the author utilizes relevant literature to support the information provided in the case report.


Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

Comments: The length of the paper appears to be appropriate for the case report and its significance. It provides a detailed description of the patient's medical history, diagnosis, treatment, and outcomes, including relevant images and scans. Additionally, it connects the case to existing literature and discusses the potential implications.

Writing style

Q: Is it clear and understandable?

A: The writing style in the provided excerpt appears to be generally clear and understandable, especially considering the technical and medical nature of the content. The writing is organized into sections that follow a logical flow, and it conveys information about the patient's case, diagnosis, treatment, and outcomes. Technical terms and medical terminology are appropriately used, which is important for maintaining accuracy in a scientific case report.

Further comments on the paper


Overall, the case report titled "A Long-Term and Sustainable Response to Orapali in a BRCA2 Mutant Advanced Pancreatic Cancer: A Case Report" provides valuable insights into the potential efficacy of PARP inhibitors in treating advanced pancreatic cancer with BRCA2 mutations. The paper presents a detailed description of the patient's medical history, diagnosis, treatment, and outcomes, which contributes to the growing body of evidence regarding precision medicine approaches in oncology.


The abstract effectively summarizes the key points of the case report, making it easy for readers to understand the study's scope and findings at a glance. The use of specific keywords facilitates discoverability for researchers interested in similar topics.

The inclusion of CT scan images and descriptions provides visual context for the patient's journey and adds to the clarity of the narrative. The legends and notations associated with the images are essential for interpreting the results accurately.

Q: Would you recommend this manuscript for further publication?

A: Yes - This manuscript is recommended for further publication.

If you have any questions and clarifications you can write to the journal.

Science Repository Team


Author Info

Corresponding Author
Xiuming Zhu
Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

Article Info

Article Type
Case Report
Publication history
Received: Tue 15, Aug 2023
Accepted: Wed 30, Aug 2023
Published: Thu 07, Sep 2023
© 2023 Xiuming Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.SCR.2023.05.03