Treatment of Pulmonary Hypertension in POEMS Syndrome with Autologous Stem Cell Transplantation

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments: The Discussion section not only analyses the different factors responsible for the pathogenesis of pulmonary hypertension (PH) but also provides useful information on various treatment options for treating underlying plasma cell dyscrasia (PCD). It elaborates on the importance of right heart catheterization (RHC) as a diagnostic method and autologous stem cell transplantation in the treatment of PH associated with POEMS syndrome. Figures and tables are also briefly explained.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This is the first case report, involving a 65-year-old female with pulmonary hypertension (PH) associated with POEMS syndrome, demonstrating the significance of autologous stem cell transplantation (ASCT) as a life-prolonging treatment option for treating plasma cell dyscrasia (PCD) with improved survival and better outcomes. The improvement in hemodynamics measured by right heart catheterization (RHC) concludes the accuracy and precision of RHC in detecting changes in hemodynamics and is considered as the gold standard for the diagnosis of PH.

Q: Would you recommend this manuscript for further publication?

A: Yes- Suitable to be published

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Science Repository Team