Factors Influencing the Prognosis of Acute Myeloid Leukemia

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Comments: The subheading Introduction has been introduced before the subheading Materials and Methods.

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments: The Discussion establishes that it is important to analyse the factors affecting the treatment effectiveness and prognosis of patients with leukemia, to better guide the decision of clinical treatment plan. It highlights that there is a certain correlation between the long-term survival of acute myeloid leukemia (AML) patients and their age of onset. The Discussion illustrates that immunotyping can not only help to diagnose and differentiate leukemia but also act as an independent factor for risk stratification of AML. The study concludes that the prognosis of AML patients is influenced by multiple factors and the prognosis should be done according to risk factors. Also, appropriate chemotherapy regimens should be selected for patients of different age groups.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good

Writing style

Q: Is it clear and understandable?

A: Good

Comments: Except the following errors have been detected:

1.     The 1^st sentence in the 4^th paragraph under Introduction was not making sense and should be changed to “Xiaoli Wang had performed such a study on survival in acute myeloid leukemia a negative phase relationship with age, but Claudia Bănescu et al. has shown…. total survival.”

2.     The 1^st sentence in the 3^rd paragraph under Discussion was not framed properly and should be changed to “Through the observation of the clinical situation, the long-term survival of patients with clinical symptoms and the long-term survival in patients with no evident difference between the original amount of young cells and bone marrow comparative there is no…. chemotherapy.”

3.     The full form of the abbreviations GT and MDS have not been mentioned.

 Further comments on the paper

Comments: The study aims at investigating the prognostic factors influencing adult acute myeloid leukemia (AML) in a study population of 51 AML patients. The study has observed that age and the history of MDS prodrome were independent prognostic factors affecting overall survival (OS). The study illustrates that appropriate chemotherapy regimens should be selected for patients of different age groups to achieve complete remission (CR) in the early stage. It highlights that allogenic hematopoietic stem cell transplantation (HSCT) should be carried out as far as possible for high-risk cytogenetics patients to extend the survival time and improve the quality of life. The study illustrates that bone marrow transplantation is an effective treatment option. However, transplant-related mortality remains high, thereby limiting improvement in OS. The study concludes that the prognosis of AML patients is influenced by multiple factors and the prognosis should be done according to risk factors.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions and clarifications you can write to the journal.

Thanks,
Science Repository Team