Induction Chemotherapy Docetaxel, Cisplatin, 5-Fluorouracil Followed by Concurrent Chemoradiotherapy in Stage IVA Nasopharyngeal Carcinoma

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The Results are aptly supported by data and encompass all the relevant findings of the study including the compliance and tolerance and the acute toxicities of induction TPF (docetaxel, cisplatin and 5-fluorouracil) and CCRT (concurrent chemoradiotherapy). The Discussion puts forth the rationale for taking up the study, effectively describes the relevant literature and enlists the implications of the findings from the present study in that context. The study concludes that the standard dose TPF followed by CCRT is well tolerated in Chinese patients with manageable toxicities and allows adequate dosage of concurrent cisplatin to be delivered subsequently.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This retrospective study aims to explore the tolerability of docetaxel, cisplatin and 5-fluorouracil using standard dose in Chinese patients with stage IVA nasopharyngeal carcinoma and report on its preliminary efficacy. The study is of significance since nasopharyngeal carcinoma (NPC) has a unique endemic distribution and approximately 129,079 new cases are diagnosed each year worldwide. Patients treated with TPF followed by concurrent chemoradiotherapy from January 2017 to January 2020 are retrospectively reviewed. The limitations of this study include a small patient sample, relatively short median follow-up of 2 years and the retrospective nature of the study with inherent record bias.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team