Genetic Mutations and Their Clinical Implications in Older Patients with Acute Myeloid Leukemia

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Comments:

·       The heading "Intruction" should be corrected to "Introduction".

·       The word "Compare" in the first three subheadings under "Results" should be replaced with "Comparison".

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good.

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The Discussion section summarizes from the results of the review that aged Acute Myeloid Leukemia (AML) patients have more obvious clinical biology characteristics, and higher risk frequency of cytogenetic and gene mutations, with worse prognosis than the younger patients. It also provides the distribution of genetic changes and different results of gene mutations in different age groups of patients. This study therefore is of great value for the development of newer and targeted therapy and for the improvement of clinical results of aged patients with adverse prognosis.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This retrospective study focuses on the genetic mutations of older patients with AML, exposing their prognostic implications. The survival rate of elder patients with AML is quite low and reports regarding the clinical significance about AML gene mutation in aged patients are very rare. The relationship between gene mutation of aged AML patients and its clinical significance still remains less explored. In this study, the clinical, cytogenetic and laboratory data of 427 de novo non-M3 AML patients from January 2000 to March 2014 were analyzed and relevant mutations in 21 genes between AML patients aged 60 years or older and those younger were compared.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team