Targeting UCP2 Suppresses the FAK Signaling and Progression of Human Head and Neck Cancer Cells
Targeting UCP2 Suppresses the FAK Signaling and Progression of Human Head and Neck Cancer Cells
Review Data
Purpose and Significance of Study: This study first demonstrates targeting UCP2 could suppress H&N cancer progression, and FAK may serve as the upstream signaling molecule regulated by UCP2. It may provide a rationale for targeting UCP2 in future therapeutic studies with respect to H&N cancer.
Fit with Scope of Journal: The manuscript is of very high interest for the journal Clinical Oncology and Research.
o The manuscript is well-written. It has a few minor errors (already corrected in the galley proof), which are listed below –
· A common issue is the omission of “,”, e.g., after “US” in the 2nd sentence of the 1st paragraph of Introduction, after “(UCP2)” in the 1st sentence of the 2nd paragraph of the Introduction, and so on.
· There is no need of using the full form after introducing the abbreviation “UCP2”.
· “four h” must be replaced with “4 h” under Cell proliferation assays and Cell migration and invasion assay in the Methods.
· In the heading Mitochondrial respiration and lactate production was suppressed in UCP2 KD H&N cancer cells in the Methods, “was” must be replaced with “was”.
· In the very last sentence, “that” must be inserted after “demonstrates”.
Cherie Ann Nathan
Chunjing Zhang
Hongyan Du
Manikandan Panchatcharam
Sumitra Miriyala
Yunfeng Zhao
Author Info
Corresponding Author
Yunfeng Zhao
Department of Pharmacology, Toxicology & Neuroscience, LSU Health Sciences Center at Shreveport, Louisiana, USA
Article Info
Article Type
Research Article
Publication history
Received: Thu 09, Apr 2020
Accepted: Fri 24, Apr 2020
Published: Wed 29, Apr 2020
Copyright
© 2023 Yunfeng Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.04.09