Aqueous Extract of Fagara tessmannii Engl. (Rutaceae) Exhibits Antihypertensive Activity in NO Synthase Inhibitor-Induced Hypertensive Rats

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Author Info

Yannick Bekono Fouda Esther Ngo Lemba Tom Bibi-Farouck Aboubakar Oumarou Lohik Nguegang Mbolang Adélaïde Marie-Noël Tegah Kuissu Paul Désiré Dzeufiet Djomeni Théophile Dimo

Corresponding Author

Théophile Dimo
Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaoundé I, Yaoundé, Cameroon

A B S T R A C T

Background: Most cardiovascular troubleshot ultimately result of endothelial dysfunction-induced hypertension, an intractable problem in modern medicine. Fagara tessmannii, a shrub of the African rainforests found in Cameroon is traditionally used to treat heart diseases and hypertension. This study aimed to evaluate the preventive effects of the aqueous extract of F. tessmannii (AEFT) on arterial hypertension induced by NG-Nitro-L-arginine-methyl ester (L-NAME). Methods: Male Wistar rats received saline (5 mL.kg-1 , intraperitoneally) or L-NAME (25 mg.kg-1 ; intraperitoneally), L-NAME + AEFT (100 or 200 mg.kg-1 ; orally) or captopril (20 mg.kg-1 ; orally) for three weeks. Then, blood and pulse pressures (BP and PP), heart rate, lipid profile, kidney, liver and heart function markers and oxidative status were evaluated. Results: AEFT (100 and 200 mg.kg-1 ) prevented the increase in BP (p < 0.001), PP (p < 0.01), and heart rate (p < 0.05) induced by L-NAME. The extract has suppressed the decline of weight gain, visceral fat and triglyceridemia, decreased total cholesterol, increased HDL-cholesterol, and significantly reduced (p < 0.001) atherogenic and coronary risk indicators. AEFT also improved the liver, kidney and heart markers, nitrites levels and prevented TBARS enhancement as compared to the hypertensive group. The remodeling of the media and fibrosis process in coronaries were also prevented by the extract. Conclusion: These results suggest that AEFT can prevent endothelial dysfunction-induced hypertension, dyslipidemia and associated atherogenic risks, and oxidative stress induced by L-NAME.

Article Info

Article Type

Research Article

Publication history

Received: Thu 27, Aug 2020
Accepted: Fri 11, Sep 2020
Published: Wed 30, Sep 2020

Copyright

© 2023 Théophile Dimo. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JICOA.2020.05.07