Tight Junction Protein Junctional Adhesion Molecule-A Regulates the Expression of Receptor Tyrosine Kinase EPHA2 In Triple-Negative Breast Cancer Cells

Author Info

Sri HariKrishna Vellanki Viviana Bustos Brian J. Harvey Ann M. Hopkins

Corresponding Author

Ann M. Hopkins
Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland

A B S T R A C T

Breast tumors lacking expression of the human epidermal growth factor receptor-2 (HER2), progesterone receptor (PR) and estrogen receptor (ERα) are defined as triple negative breast cancers (TNBC). A lack of targeted therapies has impaired TNBC patient prognosis. It has previously been shown that high expression of Junctional Adhesion Molecule-A (JAM-A) correlates with aggressive breast cancer patient phenotypes, and that JAM-A regulates the expression of HER2 in breast cancer cells. Accordingly, we hypothesized that JAM-A might regulate the expression of other receptor tyrosine kinases. We show for the first time that JAM-A may regulate the expression of the EPHA2 receptor in TNBC cells and propose that this pathway merits deeper investigation for its therapeutic value in TNBC settings.

Article Info

Article Type

Short Communication

Publication history

Received: Wed 03, Jul 2019
Accepted: Fri 26, Jul 2019
Published: Sat 10, Aug 2019

Copyright

© 2023 Ann M. Hopkins. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2019.04.01