The Significance of p53 and Estrogen Expression in Endometrial Hyperplasias and Endometrioid Carcinomas

Author Info

Ayse Nur Akatlı Cemil Colak Ebru Inci Coskun Ercan Yilmaz Nurhan Şahin Nusret Akpolat Umran Karabulut Dogan

Corresponding Author

Nurhan Şahin
Bezmi Alem University Hospital Pathology Department, Istanbul, Turkey

A B S T R A C T

Objective: Endometrial carcinomas are the most commonly encountered malignancies of the female genital system. The tumours are sub-classified into two types; type I, endometrioid carcinoma (EC) and type II, serous carcinoma (SC). Accumulation of p53 protein have been detected in SC whereas they are not common in endometrial hyperplasia and EC. Materials-Methods: This study is a retrospective evaluation of 51 endometrioid carcinomas, 46 endometrial hyperplasias with/without atypia. In all three groups, the correlations between epithelial/ stromal p53 and estrogen expression (ER) and cervical, myometrial and lymphovascular invasion and relationship tumour grades were determined. Results: Significant differences were noted between hyperplasia with atypia and non-hyperplasic endometria, epithelial p53 immunostaining (p<0.05). ER expression were stronger in hyperplasias with/without atypia than EC in both epithelial and stromal components (p<0.05). The relationship between tumour grade and p53 and ERs epithelial/ stromal expression was investigated however no statistically significant correlation was found. Conclusion: The present study found that, most EC cases have a higher p53 but lower ER expression. P53 expression can be used as an indicator of tumour aggressiveness. In addition to known factors that need to be considered when evaluating endometrioid carcinomas and their precursor lesions, first glance importance should be given to epithelial expression of p53 and stromal expression of ER.

Article Info

Article Type

Research Article

Publication history

Received: Tue 13, Feb 2018
Accepted: Thu 22, Feb 2018
Published: Wed 07, Mar 2018

Copyright

© 2023 Nurhan Şahin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2018.10.001