Successful Treatment of Prepouch Ileitis with Oral Mesalamine in Barnett Continent Ileal Reservoir

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The case description is adequate. The Discussion explains the challenges in treating the patient in the present case clearly. It also offers useful suggestions with respect to the treatment regimen. It also adequately discusses the literature. The study recommends the use of oral mesalamine as long-term maintenance therapy as there was complete resolution of inflammation and ulceration of the prepouch afferent limb on endoscopy and histology, along with the resolution of symptoms with the use of oral mesalamine.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This case report presents the case of a 65-year-old male patient in which prepouch ileitis in Barnett Continent Ileal Reservoir (BCIR) was successfully treated with oral mesalamine. There are scant data in the management of pouchitis and prepouch ileitis (PPI) in patients with Barnett Continent Ileal Reservoir. Till date, the use of oral mesalamine in the treatment of PPI or in the treatment of inflammatory conditions in the continent ileostomy has not been described. This study holds significance as this is the first case in the literature showing that mesalamine is safe and effective in the treatment of prepouch ileitis in a patient with a continent ileostomy.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team