Clinicopathologic Characteristics and Treatment Outcomes of Rectal Gastrointestinal Stromal Tumors: A Retrospective Study
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Abstract & Keywords
Q: Are all required components included in the abstract? Are the keywords appropriately chosen?
A: Very Good
Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?
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Tools and Methods
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Discussion & Conclusion
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Comments: The Discussion establishes that the study analyses the clinicopathologic characteristics, surgery approach, the usage of imatinib and follow-up outcomes of rectal gastrointestinal stromal tumors (GISTs) in a study population of 49 patients. The Discussion highlights that the rectal GISTs have a much lesser prevalence as compared to GISTs occurring in the stomach and small intestine. Also, the clinical features and treatment outcomes of the rectal GISTs are not well documented. Digital rectal examination can be used to detect the lesions and gastrointestinal endoscopy, contrast-enhanced CT and MRI are the common diagnostic methods. The Discussion illustrates that clinical characteristics, development and outcome of rectal stromal tumors should be properly understood to implement individualized treatment plans for patients. The study concludes that the complete resection of the tumor is the cornerstone of treatment for localized GISTs. Although, in the study population, the recurrence rate showed no difference in each group in the present follow-up, long term follow-up is needed to better understand the outcome.
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A: Very Good
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Figures & Tables
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Comments: Except the following errors were detected:
1. The words “clinicopathologic” and “abdominoperineal” have been misspelled in the text.
Further comments on the paper
Comments: The study analyses the clinicopathologic characteristics, surgery approach, the usage of imatinib and follow-up outcomes of rectal gastrointestinal stromal tumors (GISTs) in a study population of 49 patients. Four kinds of surgeries were used out of which trans-anal/trans-perineal and trans-sacral were the commonly used surgical methods. The complications and mortality rate associated with surgery is extremely low. The possible reasons for recurrence rate and metastasis rate not being statistically significant in the two groups could be that the sample size is not large enough and the follow-up time is relatively short. Future multi-centered prospective researches will be needed to improve the diagnosis rate before the operation, to correctly choose the operation method, to determine the dose and time limit of imatinib treatment in the perioperative period.
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A: Yes - Suitable to be published
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Corresponding AuthorChujun Li
Department of Gastrointestinal Endoscopy, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China
Article TypeResearch Article
Publication historyReceived: Tue 20, Apr 2021
Accepted: Tue 04, May 2021
Published: Mon 31, May 2021
Copyright© 2021 Chujun Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.