Differential Expression of Blood Group Precursor Antigen in Human Breast Cancer Tissue
§ Significance of the Study: This pilot study offers a valuable insight into the importance of the expression of breast cancer antigen (BCA) biomarkers which can provide information about clinical and pathological features and prognosis to guide treatment stratification. This study, involving 52 breast tissue specimens, examines the expression of a tumor-specific, conserved epitope of oncofetal blood group precursor antigens, gpC1, in breast cancer (BCA) patients using tissue microarrays (TMAs). Further research on gpC1 expression level, its relationship with BCA progression and comparisons with traditional BCA cell lines with cancer stem cells (BCSC) markers is required.
§ Fit with the Scope of the Journal: The manuscript perfectly fits with the scope of the International Journal of Cancer Science & Therapy.
§ The Discussion is well supported with the observations and is aptly analysed. It also adequately discusses the literature relevant to this study. The study findings are appropriately presented in the Conclusion section. Figure and table are also briefly explained.
§ The manuscript is mostly well-written except a few minor errors (already corrected in the galley proof) that are listed below:
o Words like “triple-negative”, “cross-reactivity” should be hyphenated.
o The word “overexpressed” should be written as a single word.
o In the 1st sentence of the Abstract, “of” should be replaced with “for” before “biomarkers”.
o In order to maintain the consistency, “BCa” should be written as “BCA”.
Tumor Glycomics Laboratory, SRI International Biosciences Division, Menlo Park, California, USA
Received: Wed 22, Jul 2020
Accepted: Wed 05, Aug 2020
Published: Fri 14, Aug 2020
© 2021 Denong Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.