Clinical and Prognostic Analysis of Adult Acute Lymphoblastic Leukemia

Clinical and Prognostic Analysis of Adult Acute Lymphoblastic Leukemia

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and exciting for researchers?

A: Good


Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very Good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good


Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Good


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them coherent?

A: Very Good


Comments: The Discussion gives an overview of acute lymphoblastic leukemia (ALL) and suggests early risk stratification in the determination of prognosis and treatment strategy. The authors also discussed the origin of adult ALL and the research was carried out taking into consideration different age groups. The authors recommended Allo-HSCT during CR1 for patients highly likely to suffer from recurrence. The Conclusion illustrates that adult ALL patients are more prone to relapse after remission and have poor long-term survival.



Q: Does the author utilize relevant literature?

A: Good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good



Q: Is the length of the paper adequate for the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good


Figures & Tables

Q: Does the author use them suitably? Are legends and notations clear?

A: Good


Writing style

Q: Is it clear and understandable?

A: Good

Comments: There are few errors found in the manuscript, which are as follows:

·       Under Introduction, 4th paragraph, 2nd sentence, “Exploring factors affecting… formulate individualized strategy…” should be written as “Exploring factors affecting… formulate individualized strategies…”.

·       Under heading, statistical analysis, 1st sentence, “Chi-square test or Fisher exact test… treating effects” is rewritten as “Chi-square test or Fisher exact test… treating effects” is rewritten as “Chi-square test or Fisher exact test… treatment effects”.

·       In Discussion, 1st paragraph, 3rd sentence, “Early risk stratification is helpful to determine outcome and guide treating strategy” must be written as “Early risk stratification is helpful in determining outcome and guide treatment strategy”.


Further comments on the paper

Comments: The research analysed and illustrated the clinical characteristics of 65 adult patients diagnosed with acute lymphoblastic leukemia (ALL) and put forth the prognostic factors to provide evidence for the stratification of prognostic risk and the formulation of the individualized therapy. The study has elucidated the overall patient data, treatment strategy, and efficacy of evaluation. The results also described the statistical and survival analysis of the patient data and screened out the valuable predictive factors.


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions or clarifications you can write to the journal.

Science Repository Team



Author Info

Corresponding Author
Bao-An Chen
Department of Hematology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province, China

Article Info

Article Type
Research Article
Publication history
Received: Thu 20, Oct 2022
Accepted: Wed 02, Nov 2022
Published: Fri 11, Nov 2022
© 2023 Bao-An Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2022.04.04