Clinical Heterogenicity in Children with Ovotesticular Disorder of Sex Development: Experience at Children’s Hospital of Mexico Federico Gomez

Clinical Heterogenicity in Children with Ovotesticular Disorder of Sex Development: Experience at Children’s Hospital of Mexico Federico Gomez

Review Data


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Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for researchers?

A: Very good


Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good


Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Good


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them coherent?

A: Very good



The study is well designed and executed. The Methods and Results are adequately described. The Discussion offers a thorough and detailed analysis of the findings of the present study taking all the relevant literature into account. The study is well supported with briefly explained table. The study aptly recommends a scrupulous clinical examination, as well as hormonal, imaging, genetic and molecular investigation for a correct diagnosis since actual management and decision on gender assigning and treatment is challenging and debatable. The Conclusions are consistent with the evidences presented in this article.



Q: Does the author utilize relevant literature?

A: Very good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good



Q: Is the paper's length adequate to the topic's significance? Do you suggest shortening the paper without losing its value?

A: Good


Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good


Writing style

Q: Is it clear and understandable?

A: Very good


Further comments on the paper

Comments: This retrospective study evaluates the clinical presentation, phenotype, gonadal features, gender assignment and medical management on patients diagnosed with ovotesticular development sex disorders (DSD). This study holds significance as this condition is quite rare and unexplored. Only few studies in the literature address this issue. The retrospective nature of the study, small number of cases, all patients not being investigated for the presence of the SRY gene or other genetic alterations associated with ovotesticular DSD and onset of puberty due to lack of prospective follow-up come out as some of the limitations of the study.


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

Science Repository Team



Author Info

Corresponding Author
Jorge Mario Molina Díaz
Medical Specialist in Pediatric Endocrinology, Department of Child Endocrinology, Federico Gómez Children´s Hospital of Mexico (HIMFG), Associate Professor Autonomous University of Mexico (UNAM), Mexico City, Mexico

Article Info

Article Type
Research Article
Publication history
Received: Tue 30, Aug 2022
Accepted: Mon 19, Sep 2022
Published: Sat 01, Oct 2022
© 2023 Jorge Mario Molina Díaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2022.04.01