Strategizing the Treatment Approach to Acute Myeloid Leukemia

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The article is a timely and adequately detailed and thorough discussion of the ongoing developments in treatment strategies for acute myeloid leukemia (AML), especially in terms of the mechanisms of cell signaling and biology of cytogenetic and molecular markers that drive AML and promote leukemogenesis. The authors conclude that targeted treatment now changes prognostic models as mutations of poor prognosis can be subdued with therapy, and the outcomes of ongoing clinical trials are intriguing for the potential to achieve durable remission in AML without the use of intense chemotherapy and preserving patient functional status and quality of life.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Not applicable.

Writing style

Q: Is it clear and understandable?

A: Very good

Comments: A few minor issues were noted:

·       “ozogamicin” and “trials” are misspelled.

·       In the 7^th sentence of the last paragraph of Maintenance Therapy, “impact” must be removed.

·       Articles (a, an, or the), commas, and hyphens were missing in some places.

Further comments on the paper

Comments: This review highlights the discovery of treatment strategies to improve patient outcomes and ongoing research in acute myeloid leukemia (AML). It discusses the timing of first therapy, non-intense treatment regimens achieving remission, and new targets for directed therapy; key clinical trials are referenced, which expand the discussion of newly approved agents for AML. This is significant as treatment discovery provides therapeutic opportunity to older patients and populations previously excluded from intense induction chemotherapy.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions and clarifications you can write to the journal.

Thanks,
Science Repository Team