Response Evaluation with Dynamic FDG PET/CT during the Primary Systemic Therapy of Breast Cancer - A Case Report

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Comments:

Minor errors (already corrected in the Galley Proof) are as follows:

• The subheadings Materials and Methods, Case Presentation and Results have been realigned.
• In the 5^th sentence under “Abstract”, “described case we can concluded” should be changed to “described case we concluded”.
• In the 4^th sentence under “Case Presentation”, “of he left breast” should be corrected to “of the left breast”.

·       Under “Results”, the spelling of “epirubicine” should be corrected to “epirubicin”.

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The Discussion encompasses the relevant findings from the previous studies on FDG PET/CT imaging and provides a thorough analysis of the findings and their implications. It offers a thorough and detailed analysis of the findings of the present case taking all the relevant literature into account. The study is well supported with figures and tables which are briefly explained. Based on the presented case, the study Concludes that dynamic PET/CT is suitable for accurate quantification of FDG-uptake also in primary breast tumors. The study further recommends use of interim PET/CT scan in cases with clinically controversial baseline tests.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This case report describes the experiences with staging, interim and restaging dynamic PET/CT examinations of a 45-year-old woman suffering from breast cancer. 18­fluorine­fluorodeoxyglucose (FDG) positron emission tomography (PET) and mainly combined with computed tomography (CT), abbreviated as FDG PET/CT is a useful and accurate tool for staging and restaging in locally advanced breast cancer. The study holds significance as it shows that dynamic PET/CT is suitable for accurate quantification of FDG-uptake in primary breast tumors. In case of the presented case, the processes characterized by K1 and k2 (FDG-uptake into the cell and FDG-release from the cell) were dominant in the primary tumor at all three PET/CT scans, in addition to low k3.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team