Pathology and Diagnosis of Mantle Cell Lymphoma

Pathology and Diagnosis of Mantle Cell Lymphoma

Review Data

Purpose and Significance of Study: This is a review of the current understanding of the pathology and the prevalent diagnostic approach for mantle cell lymphoma, a rare B-cell non-Hodgkin lymphoma with a dismal prognosis (hence requiring aggressive and often novel therapy), thus making an accurate diagnosis paramount.

Fit with Scope of Journal: The manuscript is of very high interest for the journal Annals of Clinical Oncology.

This review lays down the need for rapid and accurate diagnosis of MCL, adequately covers the various aspects of the pathology of MCL, including subtypes, pathogenesis, morphology, immunophenotype, and genetic features, and also the differential diagnoses of MCL.


o   The manuscript contains some minor errors (already corrected in the galley proof, except the highlighted one, which requires the author’s attention) listed below –


·       “Cyclin D” was misspelled as “Cycle D” multiple times.

·       The 2nd and 3rd sentences of Immunophenotype under Pathology of MCL, i.e., “Pan B cell…FMC7” and “While CD23…Cyclin D1 expression” are poorly constructed, making them hard to read or understand; hence, they must be re-phrased.

·       Words like “overexpression”, “upregulation”, “subtype”, “subgroup”, “extranodal”, “immunohistochemistry”, etc. must be written as single words without hyphens.

Author Info

Corresponding Author
Ezzat Elhassadi
Consultant Haematologist, Honorary Clinical Lecturer for UCC & RCSI, Clinical Director for Haematology and transfusion services, University Hospital Waterford, Ireland

Article Info

Article Type
Review Article
Publication history
Received: Fri 29, May 2020
Accepted: Wed 10, Jun 2020
Published: Tue 16, Jun 2020
© 2023 Ezzat Elhassadi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.ACO.2020.02.02