Carcinoma Showing Thymus-Like Differentiation (CASTLE): A Rare Tumor of the Thyroid

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The case description is adequate. The Introduction lays down the basics for taking up the present study. The Discussion explains the challenges in treating the patient in the present case clearly. It also offers useful suggestions with respect to the treatment regimen. The Discussion provides an apt analysis of the histologically prominent features of CASTLE such as lobulation on cut surfaces, thick bands within the tumor etc. Thymus-like tumors are rare tumors that arise from the thyroid or adjacent soft tissues. The case report finally throws light upon the treatment stating that surgery can improve the survival of patients and radiotherapy can be reserved for patients with extrathyroidal extension and lymph node involvement.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This case report presents the case of a 52-year-old female patient with carcinoma showing thymus-like differentiation (CASTLE). The study holds significance as CASTLE is a rare neoplasm of the thyroid or the adjacent tissues in the neck. CASTLE exhibits malignant characteristics and both sexes are affected similarly with a slight female dominance. The findings of the study well support the diagnosis. According to the literature review, expression of CD5, HMWCK, CEA and p63 in CASTLE were useful markers to confirm the diagnosis. The report further states that due to limited number of patients, choice of treatment is controversial.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team