Large Retroperitoneal Perivascular Epithelioid Cell Neoplasm (PEComa): A Case Report and a Brief Review

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Good

Comments: The title has been modified.

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments: The Discussion describes the rarity of occurrence of the PEComas, providing relevant literature. It further suggests contrast ultrasonography, contrast-enhanced computed tomography, and magnetic resonance imaging for the diagnosis of PEComa and provides several lines of systemic therapies. Lastly, the Discussion highlights immunohistochemical staining as the correct diagnosis method.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good

Writing style

Q: Is it clear and understandable?

A: Good

Comments: There are few issues found in the manuscript which are as follows:

·       In Case Report under Abstract, 2^nd sentence, “After multidisciplinary evaluation… adrenalectomy has been performed” must be written as “After multidisciplinary evaluation… adrenalectomy”.

·       Under the Introduction, 3^rd sentence, “Microphthamia transcription factor -Mift” must be “Microphthalmia transcription factor – Mitf”.

·       Under heading Case Report, 4^th sentence, “Contrast TC scan did not show cranium or chest nodularities” should be “Contrast CT scan did not show cranium or chest nodularities”.

Further comments on the paper

Comments: This Case Report presents a 42-year-old female with abdominal pain and urinary complications. Clinical imaging revealed a huge inhomogeneous mass occupying the right abdomen and arising from the renal capsule, which was later diagnosed as perivascular epithelioid cell tumor (PEComa). The report further discussed the surgical and treatment procedure for the complete removal of the tumor.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Thanks,
Science Repository Team