Zebrafish Heart as a Model to Elucidate the Mechanisms of Sudden Cardiac Death

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The relevance of sudden cardiac death in humans, advances in knowledge of the development, function and pathologies in the zebrafish heart model and the possibility of using the zebrafish model for the study of sudden cardiac death are the three related points highlighted as well as discussed in this mini review. The Conclusions are consistent with the evidences presented in this article and covers how the wide acceptance of zebrafish in research, the increasingly abundant information on its normal and pathological cardiovascular processes, its short life cycle and its genetic and functional similarities to humans, make it an integrated model option to study sudden cardiac death which is a multicausal health problem affecting individuals of various ages, races and gender.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This review presents the advantages of zebrafish model considering the genetic, molecular and physiological information available on cardiovascular development and function throughout its life cycle to study sudden cardiac death. The significance of this study lies in the fact that existing works contain little or no information on zebrafish as a model to study sudden cardiac death. Sudden cardiac death is the most common lethal outcome of many cardiovascular diseases, and it can occur in any age group, race or sex. Due to the multiple limitations of clinical research such as high economic costs, complex logistics, and bioethical considerations, basic research with animal models is a necessary alternative to investigate this area.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team