Underlying Causes of High Output Heart Failure

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Not applicable.

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments: The apt analysis of this study leads to a conclusion that highlights the underlying pathophysiologic mechanisms associated with high output cardiac failure. It states that obesity, arteriovenous fistula, liver disease, hyperthyroidism and severe anemia result in high output heart failure which is characterized by increased metabolic demand and decreased systemic vascular resistance. Further research is required to better understand the regulation of vascular tone and fluid retention in obese patients as obesity is one of the most potent risk factors for this disease.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Not applicable.

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This review article provides a valuable insight into the underlying pathophysiologic mechanisms, prevalence and clinical causes of high output heart failure. High output heart failure is associated with low systemic vascular resistance, reduced arterial-venous oxygen gradient and an elevated cardiac output and it occurs when elevation in overall cardiac output fails to meet the metabolic demands of the body. Obesity, arteriovenous fistula, liver disease, hyperthyroidism, severe anemia and mitochondrial disease contribute to the pathogenesis of this disease. This study is of significance as the underlying etiology predicts the clinical manifestations of high output cardiac failure.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team