Clinical Features and Treatment Outcomes in Patients with Extracranial Germ Cell Tumors: A Tertiary Centre Experience

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The Discussion section highlights that most of the patients presenting to the tertiary care centre were in advanced stage with high nodal burden disease. However, those who presented in early stage, with favorable histology and underwent multidisciplinary cancer care enjoyed a good long survival. Further it states that the most commonly affected age group were 31-40 years in males and 11-20 years in females. The Conclusion puts emphasis on proper investigations and referral, if any suspicion of malignancy is encountered as germ cell tumor is primarily a disease of young and adolescents.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This retrospective study reports the experience of extra-cranial germ cell tumors at a tertiary referral centre, focusing on demography, histopathology, management, outcome and prognosis. It aims to evaluate the extracranial germ cell tumors with regards to gender, age, clinical presentation, pathology, management, acute toxicity and survival. The study is of significance as germ cell tumors are very rare and its incidence is increasing with time. There is a lack of recent data from India on epidemiology of germ cell tumors.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team