New Advances in Classical Wnt/β-Catenin Signaling in Cancer

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The intrinsic link of Wnt signaling pathway to cancer stem cells is appropriately discussed in this review, aiming to curb the malignant progression of tumors from the root cause. Possible clinical strategies harnessing the classical Wnt signaling pathway as a therapeutic target are aptly summarized in the Conclusion. Due to its complexity, however, Wnt/β-catenin signaling is still being explored as a target for the treatment of cancer. 

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This review introduces the underlying mechanism of Wnt signaling pathway and highlights the most recent research progresses on the relationship between Wnt signaling pathway and tumor. Emerging evidences show that Wnt/β-catenin-mediated signaling is a key pathway regulating tissue growth and development, and tumorigenesis. Because of its role in determining cell fate and promoting tissue development, Wnt signaling has become the focus of current researches in regenerative medicine. The adverse effects of Wnt signaling in tumors prompts researchers to study extensively to decode its mechanisms of action in cancer and to find valuable targets to expand cancer treatment strategies. 

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team