Photodynamic Therapy Excited by Cerenkov Radiation from Cesium-137 Irradiator: In Vitro Studies
Photodynamic Therapy Excited by Cerenkov Radiation from Cesium-137 Irradiator: In Vitro Studies
Review Data
Purpose and Significance of Study: The results indicate that the Cerenkov radiation generated from high energy g-rays from Cesium-137 can be used to activate the second-generation photosensitizer pyropheophorbide-a methyl ester in photodynamic therapy (PDT), which can potentially overcome the penetration limitations of optical photon based PDT, making PDT a feasible and complementary cancer therapy for deep lesions.
Fit with Scope of Journal: The manuscript is of very high interest for the journal Clinical Oncology and Research.
The Results clearly elaborates on the dose calibration results of the Cesium-137 irradiator and the effect of the Cerenkov radiation excited PDT in the A549 lung carcinoma cell line. This may in future be used to treat deep cancer alone, or as a complementary treatment with radiotherapy, in which the high-energy photons excite the photosensitizer to reduce the radiotherapy time for fewer side-effects from radiation.
o The manuscript is well-written. Some very minor errors (already corrected in the galley proof) are listed below –
· “Cherenkov” in the 5th sentence of the 4th paragraph of the Introduction must be replaced with “Cerenkov” for the sake of consistency.
· In the 1st sentence of Cs-137 irradiator dose calibration under Method, “then” must be replaced with “thus”.
· In the 1st sentence of the 2nd paragraph of Cerenkov radiation excited PDT in vitro, “are” before “shown” must be replaced with “as”.
Yiping Guo
Shi Sheng
Michael C. Lun
Shih-Ming Tsai
Wei-Chun Chin
Roy Hoglund
Changqing Li
Author Info
Corresponding Author
Changqing Li
Quantitative and Systems Biology Graduate Program, School of Natural Sciences, University of California, Merced, California, USA
Article Info
Article Type
Research Article
Publication history
Received: Sat 16, May 2020
Accepted: Wed 03, Jun 2020
Published: Mon 15, Jun 2020
Copyright
© 2023 Changqing Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.06.07