Aggregatibacter actinomycetemcomitans and Atherosclerosis

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Author Info

Dinh Tam Nguyen Jack Anesi Michelle Steicke Yutang Wang

Corresponding Author

Yutang Wang
Discipline of Life Sciences, School of Science, Psychology and Sport, Federation University Australia, Ballarat, Victoria, Australia

A B S T R A C T

Periodontal disease is an inflammatory condition around the teeth which affects 20-50% of the worldwide population. In periodontal disease, the bacterial plaque destroys the epithelium of the periodontal pocket and breaks the barrier that separates the tissue and the circulation, allowing oral bacteria and their endotoxins and exotoxins to enter the bloodstream. This can cause health problems, such as atherosclerosis. Aggregatibacter actinomycetemcomitans (Aa) is commonly found in patients with periodontitis and the number of Aa is associated with atherosclerotic lesion size in humans. This review focuses on Aa and atherosclerosis with an emphasis on the interaction of Aa with cell types involved in atherosclerosis formation.

Article Info

Article Type

Review Article

Publication history

Received: Mon 23, Nov 2020
Accepted: Fri 04, Dec 2020
Published: Thu 24, Dec 2020

Copyright

© 2023 Yutang Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JICOA.2020.06.06