New Advances in Classical Wnt/β-Catenin Signaling in Cancer

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Author Info

Akhlaq Ahmad Ailin Tao Mushtaq Ahmed Nadia Mushtaq Ayesha Ali Khan Qing-Xin Li Muhammad Wasim Jan Khan

Corresponding Author

Akhlaq Ahmad
Labortary of Allergy & Clinical Immunology, The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, China

A B S T R A C T

Wnt/β-catenin-mediated signaling is a key pathway regulating tissue growth and development and tumorigenesis. This signaling pathway has received much attention in recent years. In addition to participating in healthy tissue and organ development, inappropriate activation of this pathway can cause a variety of tumors and other pathologies. It also plays a critical role in many processes such as proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition and dry maintenance of human tumor cells. This review introduces the underlying mechanism of Wnt signaling pathway and highlights the most recent research progresses on the relationship between Wnt signaling pathway and tumor. Furthermore, the intrinsic link of Wnt signaling pathway to cancer stem cells is also discussed, aiming to curb the malignant progression of tumors from the root cause. Finally, possible clinical strategies harnessing the classical Wnt signaling pathway as a therapeutic target are summarized.

Article Info

Article Type

Research Article

Publication history

Received: Sat 15, Aug 2020
Accepted: Mon 07, Sep 2020
Published: Wed 30, Sep 2020

Copyright

© 2023 Akhlaq Ahmad. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.09.06