Total Body Irradiation as Conditioning Regimen for Haematopoietic Progenitor Cell Transplant: A Case Report and Literature Review

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Author Info

Diana Alonso Sánchez Lloret Sáez- Bravo Marta

Corresponding Author

Diana Alonso Sánchez
Radiation Oncology Department, Hospital Universitario de Gran Canaria Doctor Negrin, Gran Canaria, Spain

A B S T R A C T

This case study presents a young adult man with lymphoblastic leukaemia B who required total body irradiation (TBI) as a conditioning regimen for haematopoietic progenitor cell transplant (HPT) as the only curative treatment option for his oncological disease. TBI was carried out with personalised patient immobilisation, three-dimensional simulation, radiophysical planning and dosimetric calculations. A total of 12 Gy were prescribed to be administered twice a day for 3 days in a row by means of volumetric modulated intensity radiotherapy with several isocentres. The best technique for the administration of this radiotherapy is discussed because, although the clinical efficacy of the administration of this body dose has been well known for decades, technological advances have brought us new possibilities when compared to the traditional TBI (bilateral with horizontal photon beam and absorbent screen). These advances include the technique used in this case (multi-isocentre volumetric-radiotherapy), which allows a better doses distribution, reducing the dose in organs at risk (OARs) and producing less toxicity, and therefore allowing the inclusion of patients who would not tolerate a conventional TBI. In addition, this method would allow the dose to be scaled up locally in higher areas at risk with better results in the disease control.

Article Info

Article Type

Case Report & Literature Review

Publication history

Received: Wed 22, Jul 2020
Accepted: Sat 01, Aug 2020
Published: Wed 12, Aug 2020

Copyright

© 2023 Diana Alonso Sánchez. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.08.19