Liver Needle Biopsies are Poor Predictors of Histologic Tumor Grade for Midgut Neuroendocrine Tumors

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Author Info

Yi-Zarn Wang Brianne Voros David T. Beyer Eugene A. Woltering Ioni Kokodis Irma Oliva J. Philip Boudreaux M. Jennifer Ricks Ramcharan Thiagarajan Robert A. Ramirez Yvette Bren Mattison

Corresponding Author

Robert A. Ramirez
Ochsner Medical Center, Kenner, LA, USA

A B S T R A C T

Background: Our group has previously shown than neuroendocrine tumors (NETs) are heterogeneous neoplasms having histologic and functional differences between their primary tumor, lymph node, and hepatic metastases. Due to the heterogeneity of these malignancies, we hypothesized that there would be discordance between the histologic grade of surgical specimens and that predicted by preoperative biopsies. Methods: Twenty consecutive patients diagnosed with NETs of the ileum and hepatic metastasis were included. Ki-67 proliferative index and WHO 2010 histologic grade were recorded for preoperative hepatic needle biopsy and subsequent tissue-matched surgical specimens. Concordance between sample values was determined. Results: Ten males and 10 females were included in this analysis. Five and 15 patients had fine-needle aspirate (FNA) and core needle biopsies, respectively. Preoperative biopsies predicted the histologic grade of subsequent tissue-matched surgical specimens in only 65% of samples (13/20). Of the 7 values that changed grade (7/20, 35%), 4 went from intermediate (G2) to low (G1) grade [1 FNA and 3 core biopsies] and 3 went from low (G1) to intermediate (G2) grade [1 FNA and 2 core biopsies]. The corresponding interrater agreement statistic (K) was 0.251±0.230 (95% CI: -0.199-0.702), with 0.21

Article Info

Article Type

Research Article

Publication history

Received: Fri 10, Jan 2020
Accepted: Wed 29, Jan 2020
Published: Fri 31, Jan 2020

Copyright

© 2023 Robert A. Ramirez. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.01.07