Current Approaches in Dental Alveolar Abscess in Sight of Bone Related Drugs

Author Info

Adel M. Abdel-Hakem El-Shimaa M. N. Abdelhafez Salsabel M. N. A. Ali Sara Mohamed Naguib Abdelhafez

Corresponding Author

El-Shimaa M. N. Abdelhafez
Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt

A B S T R A C T

Dentoalveolar abscess, a localized accumulation of pus in the alveolar bone, can produce significant changes in alveolar bone proper that may be resulted by dental caries, trauma or pulpitis causing alveolar bone resorption or even loss. Unfortunately, it can extend vertically toward the apex of the tooth. Additionally, a periapical abscess may form in the alveolar bone adjacent to the apex of the tooth. Interestingly, many bacterial products can stimulate osteoclast formation and bone resorption of periapical tissues. This review displayed drugs that can affect bone resorption that classified as (1) Osteoclast inhibitors such as: bisphosphonates, gene therapeutic (Cathepsin K) estrogens, selective estrogen receptor modulators (SERMs), calcitonin monoclonal antibodies such as denosumab and (2) Osteoclast activators such as DMPPYT, nuclear factor-Kappa B (RANK) signaling and adrenomedullin.

Article Info

Article Type

Review Article

Publication history

Received: Mon 25, Nov 2019
Accepted: Fri 20, Dec 2019
Published: Mon 30, Dec 2019

Copyright

© 2023 El-Shimaa M. N. Abdelhafez. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.ORD.2019.01.05