Empiric Treatment of Foot Infection in Patients with Severe Diabetes

Author Info

Alexandre Sacchetti Bezerra Flavia Altheman Loureiro Carla Maria Pasquareli Vazquez Afonso Cesar Polimanti Rafi Felicio Bauab Dauar

Corresponding Author

Alexandre Sacchetti Bezerra
Instituto de Infectologia Emilio Ribas, Brazil

A B S T R A C T

Background: Despite being treated with antibiotics of broad spectrum recommended by International Consensus, severe diabetic patients with lower limb infection do not present a positive clinical evolution during empirical treatment. This study’s bacterial profile was analysed and compared with other worldwide hospital centers. Objective: To confirm the need of an individualized empirical treatment for severe diabetic patients with foot infection. Methods: Retrospective analysis of cultures and antibiograms of severe diabetic patients admitted by foot infection. Results: The results were consistent with the socioeconomic realities of developing countries. Gram-negative bacteria (52,11%) were present in most bone cultures. Results presented a high incidence of Enterococcus faecalis in both gram-positive (21,2%) and polymicrobial (34,7%) samples. Bacterial resistance with the use of ordinary antibiotics in the statistical analysis was high. Conclusion: The community infections should undergo broad spectrum empirical therapy combining amikacin (80,43%) or meropenem (72,00%) with gram-negative and vancomycin (100%) or teicoplanin (90,00%) or linezolid (74,19%) with gram-positive.

Article Info

Article Type

Original Article

Publication history

Received: Wed 22, Sep 2021
Accepted: Thu 25, Nov 2021
Published: Wed 08, Dec 2021

Copyright

© 2021 Alexandre Sacchetti Bezerra. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JICOA.2021.04.04