Differential Expression of Blood Group Precursor Antigen in Human Breast Cancer Tissue
Corresponding AuthorDenong Wang
Tumor Glycomics Laboratory, SRI International Biosciences Division, Menlo Park, California, USA
A B S T R A C T
There is a pressing need for biomarkers for targeted immunotherapy against breast cancer (BCA), the leading cause of cancer death in women. Previously, a blood group precursor O-core epitope gpC1 was found to be highly expressed in breast circulating tumor cells (BCTCs) and BCA cell lines with cancer stem cell (BCSC) features. In this pilot study, the breast tissue distribution of gpC1 was examined using tissue microarrays (TMAs). Notably, gpC1 positive cells were detected in the major histological types of neoplastic breast tissues. Conversely, none of the breast tissues derived from subjects without BCA were gpC1 positive. Thus, gpC1 expression seems to be tumor-specific but not histological type-dependent, reflecting perhaps its characteristics as a conserved epitope of oncofetal blood group precursor antigens.
Article TypeResearch Article
Publication historyReceived: Wed 22, Jul 2020
Accepted: Wed 05, Aug 2020
Published: Fri 14, Aug 2020
Copyright© 2021 Denong Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.