Menopausal Status Impairs Acute Inflammatory Recovery from Resistance Exercise

Author Info

Christopher L. Axelrod Emily Kullman Kathleen D. Little Kenneth E. Sparks

Corresponding Author

Emily Kullman
Department of Health and Human Performance, Cleveland State University, Cleveland, Ohio, USA

A B S T R A C T

The purpose of this study was to explore the effects of menopausal status on inflammatory responses to a single bout of resistance exercise (RE). Twenty pre- (N=10) or post- menopausal (N=10) women aged 18- 65 years had one repetition maximum (1RM) determined for the chest and leg press, leg and biceps curl, vertical pull down, triceps and leg extension exercises. On a separate day, participants completed a session of full body resistance exercise (RE) during which subjects performed three sets of 10 repetitions at 75% 1RM for the aforementioned exercises. Blood samples were obtained prior to, immediately, and one hour after exercise. Changes in interleukin-6, -10, and transforming growth factor beta (IL-6, -10, and TGF-β1) were determined via enzyme-linked immunosorbent assays (ELISA). IL-6 significantly increased (P<0.05) over time in both groups. Immediately post exercise levels of IL-10 were significantly lower (P<0.05) in the post-menopausal group. Changes in IL-10 correlated with 17β-estradiol levels (r2=0.45, P<0.001). Menopausal status impaired inflammatory recovery following acute RE. These changes may be attributed to menopause-induced perturbations to the hormonal milieu.

Article Info

Article Type

Research Article

Publication history

Received: Wed 11, Mar 2020
Accepted: Sat 21, Mar 2020
Published: Mon 30, Mar 2020

Copyright

© 2023 Emily Kullman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.GGR.2020.01.04