Imaging Performance of a Multimodal Module to Enhance Preclinical Irradiator Capabilities

Imaging Performance of a Multimodal Module to Enhance Preclinical Irradiator Capabilities

Author Info

Corresponding Author
Sophie Pinel
CRAN, BioSiS Department, UMR Université de Lorraine-CNRS 7039, Nancy, France

A B S T R A C T

This article highlights the performance measurements of an optical device which aims at upgrading preclinical irradiators. The evaluated device allows acquiring X-ray as well as bioluminescence images with a single sensor. The latter consists of a supercooled camera equipped with a 1024x1024 charge coupling device (each element measuring 13x13µm²). X-ray imaging is feasible, thanks to a conversion phosphor screen. Phantom acquisitions revealed a spatial resolution of 2.5 line pairs per millimetre (0.2mm) for Xray imaging and between 0.4 and 0.7mm for bioluminescence images. Image homogeneity was 0.8 for radiographic images with preclinical imaging parameters and higher than 0.9 for optical images. For functional imaging, contrast to noise ratio (CNR) ranged from 1.3 (for contrast of 2:1 and 0.1s acquisition) up to 253 (for contrast of 32:1 and 5s acquisition). CNR was related to acquisition duration. The device’s overall performance revealed that it is suitable to upgrade existing irradiators and improve laboratory capabilities toward image-guided radiotherapy.

Article Info

Article Type
Research Article
Publication history
Received: Tue 21, Jan 2020
Accepted: Sat 08, Feb 2020
Published: Fri 28, Feb 2020
Copyright
© 2021 Sophie Pinel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.02.01