Significance of Tumour Biological Markers for Overall Survival and Clinical Parameters for Disease-Free Survival in Patients with Prostate Cancer after Radical Prostatectomy

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Anna Gasinska Jaszczynski Janusz Palaczynski Mikolaj Pogodzinski Marek

Corresponding Author

Anna Gasinska
Department of Tumour Pathology, Maria Sklodowska-Curie Institute, Oncology Center, Cracow Branch, Poland

A B S T R A C T

Objective: The aim of the study was to assess the prognostic significance of pretreatment serum PSA level, immunohistochemical expression (labelling index, LI) of Ki-67, prostate-specific membrane antigen (PSMA), glucose-1 transporter (GLUT-1), vascular endothelial growth factor (VEGF), human telomerase reverse transcriptase (hTERT), as well as micro vessel density (MVD) for overall survival (OS), local recurrence-free survival (LRFS), metastatic-free survival (MFS) and disease-free survival (DFS) in a group of 130 prostate cancer (PCa) patients treated with radical prostatectomy (RP) between 2007 and 2011. Methods: In order to investigate the prognostic value of the analyzed variables in univariate and multivariate Cox analysis, the patients were divided into two subgroups based on the marker cut-off points selected by the receiver operating characteristic curves. Results: There were 83 (63.8%) cases staged pT1-2 and 47 (36.1%) staged pT3-4. The majority of tumours (53.1%) were well-differentiated (grade group G1), 49 (37.7%) moderately differentiated (G2-3) and 12 (9.2%) poorly differentiated (G4-5). In 85 patients (65.4%) the surgery was radical, 59 (45.4%) had positive surgical margins (PSM), and in 23 (17.7%) seminal vesicle(s) involvement was diagnosed. Median followup was 79 (1-148) months, during which 55 (42.3%) men died, in 12 (9.2%) local relapse and in 13 (10%) distant metastases occurred. In multivariate Cox analysis, independent negative prognostic factors for OS were: Ki-67LI >6.7% (p=0.010), PSMALI ≤51.7% (p=0.009), hTERTLI ≤20.5% (p=0.004) and lack of adjuvant treatment (AT) (p=0.013), while for MFS: seminal vesicle(s) involvement (p=0.007) and hTERTLI ≤43.8% (p=0.011). However, non-radical surgery (p=0.007), PSM (p=0.005) and AT (p=0.037) were negatively associated with DFS. Conclusion: Tumour biological markers are significant for OS and clinical parameters for DFS in PCa patients’ after RP.

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Article Type

Research Article

Publication history

Received: Mon 27, Jan 2020
Accepted: Sat 15, Feb 2020
Published: Mon 24, Feb 2020

Copyright

© 2023 Anna Gasinska. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.02.04