Assessment of The Lnc-CCAT1/miR-155a Regulatory Network in Acute Myeloid Leukemia

Author Info

Eman Saleh Magdy Mohamed Nashwa EL-Khazragy Rehab Abdelmaksoud

Corresponding Author

Nashwa EL-Khazragy
Clinical Pathology and Hematology department, Faculty of Medicine, Ain Shams University Biomedical Research department, Cairo, Egypt, P.O. box 11381

A B S T R A C T

Colon cancer-associated transcript_1 (CCAT1) is a long noncoding RNA that maps to chromosome 8q24.21, it was first discovered to be upregulated in colorectal cancer. Recent studies have observed the CCAT1 overexpression in primary human solid cancers and cell lines as well as in AML, moreover, it repressed monocytic differentiation and promoted cell growth of HL-60 by sequestering tumor suppressive miR-155. However, the prognostic value of CCAT1/miR-155a pathway in acute myeloid Leukemia (AML) has not been investigated on clinical samples. In this study, the expression levels of CCAT1 and miR_155a was measured in 150 AML patients with standard and high-risk factors; CCAT1 and miR_155a were increased by 2.7 and 5.7 folds; respectively in AML compared to healthy controls. Furtherly, upregulation of both biomarkers was significantly associated with high risk AML. Collectively, these results suggest that CCAT1 and miR_155a can be considered as a diagnostic and prognostic biomarker in AML.

Article Info

Article Type

Research Article

Publication history

Received: Wed 03, Jul 2019
Accepted: Wed 31, Jul 2019
Published: Mon 30, Sep 2019

Copyright

© 2023 Nashwa EL-Khazragy. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2019.04.04