An atypical presentation of ifosfamide-induced encephalopathy and its successful treatment with methylene blue

Author Info

Emmanuel Seront Ledoux B Samartzi V van Marcke de Lummen C

Corresponding Author

Emmanuel Seront
Medical Oncology Department; Jolimont Hospital, Rue Ferrer 159, 7100 Haine Saint Paul, Belgium

A B S T R A C T

Confusion remains a frequent event appearing during cancer course; many causes have to be excluded, including antitumoral agent-induced encephalopathy. Ifosfamide-induced encephalopathy is often underdiagnosed due to aspecific symptoms. The manifestations of this encephalopathy are usually moderate and spontaneously reversible but may also lead to coma and death. We describe symptoms of dysarthria and ataxia appearing following the second course of ifosfamide in a patient treated for sarcoma. Furthermore, methylene blue administration instantaneously reversed the process. This case report highlights an atypical presentation of encephalopathy induced by ifosfamide and the importance to consider methylene blue in this setting.

Article Info

Article Type

Case Report

Publication history

Received: Mon 02, Apr 2018
Accepted: Fri 20, Apr 2018
Published: Fri 25, May 2018

Copyright

© 2023 Emmanuel Seront. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2018.10.009