Progress in Liquid Biopsy: A possible role of neutrophils

Author Info

Feixin Liang Tao Yu

Corresponding Author

Feixin Liang
Department of Oral and Maxillofacial Surgery，Hospital of Stomatology，Guangxi Medical University，Nanning 530021，Guangxi, China

A B S T R A C T

Recently, the non-invasive and diagnostic tumor liquid biopsy technique has received widespread attention from scientists. Current clinical research focuses mainly on the detection of circulating tumor cells, circulating tumor DNA, and related tumor biomarkers. However, the problem of low sensitivity in tumor diagnosis has become more prominent. In response to this limitation, some scholars have proposed to predict the occurrence and development of tumors by detecting changes in a large number of non-tumor cells that are in contact with the tumor microenvironment. Specifically, a large number of infiltrating neutrophils are common in tumor microenvironments. Studies have confirmed that the neutrophil-associated products are closely related to tumor occurrence and development and can predict tumor development. Therefore, this article will review the current tumor liquid biopsy limitations and explore the possible role of neutrophils in early tumor detection with liquid biopsy.

Article Info

Article Type

Mini Review

Publication history

Received: Thu 14, Jun 2018
Accepted: Mon 25, Jun 2018
Published: Mon 09, Jul 2018

Copyright

© 2023 Feixin Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2018.02.004