Infranatant Portion of Microfragmented Adipose Tissue: A Promising Source of SVF for the Management of Androgenetic Alopecia

Infranatant Portion of Microfragmented Adipose Tissue: A Promising Source of SVF for the Management of Androgenetic Alopecia

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for


A: Excellent



The word "microfragmented" should be written as a single word.


Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good



The contents of the headings "Background" and "Introduction" should be clubbed together.


Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good



This study opens the possibility to use only the infranatant component of the emulsified microfragmented adipose tissue without any need of enzymatic digestion. It further concludes that the use of microcannulas, in combination with a mechanical digestion by an emulsification procedure and centrifuge, could ease stromal vascular fraction (SVF) cell isolation for regenerative treatment and could also be performed in a medical facility. Further studies are needed to deepen the understanding of the composition of this cell population for regenerative purposes.



Q: Does the author utilize relevant literature?

A: Very good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good



Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good


Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good


Writing style

Q: Is it clear and understandable?

A: Good



The full forms of the abbreviations "AA" and "SVF" must be provided in the text beside where they have been first used.


Further comments on the paper

Comments: This study aims to prove the possibility to transfer a good amount of cells of the stromal vascular fraction (SVF) and adipose-derived stem cells (ADSCs) in the infranatant portion of microfragmented adipose tissue. In order to successfully introduce ADSCs into treatment plans, the study investigates a new protocol (SEFFIHAIR™) that offers the opportunity to implant successfully only the cells of the SVF. This method is not only an important step for a proper evaluation of the clinical results, but it also offers a viable option for an easy and repeatable therapy in androgenetic alopecia (AGA) treatment.


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions and clarifications you can write to the journal.

Science Repository Team


Author Info

Corresponding Author
Alessandro Gennai
Plastic Surgeon, Private Practice, Bologna, Italy

Article Info

Article Type
Research Article
Publication history
Received: Thu 14, Jan 2021
Accepted: Thu 28, Jan 2021
Published: Fri 12, Feb 2021
© 2023 Alessandro Gennai. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.RGM.2021.01.01