Cognitive Function in Cystic Fibrosis and CFTR Modulator Therapy

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for

researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments: The Discussion highlights the cognitive domains assessed in both the ivacaftor (IVA) and Ivacaftor in combination with lumacaftor (LUM/IVA) studies showed promising results for the gene-modulator therapy in CF using different measures. It also discussed the importance of improvements in the executive functional areas. The Discussion further briefly described the limitations of the study. Lastly, the conclusion suggests that further prospective cohort-controlled studies on gene modulation therapy are required to confirm any potential neurological role of IVA and LUM/IVA.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: The research aimed at studying the effects of cystic fibrosis transmembrane conductance regulator (CFTR) modulators ivacaftor and lumacaftor/ivacaftor on cognition in two separate CF cohorts. The results significantly showed the improvement in CFTR modulator treatment. The manuscripts have illustrated the methods of the ivacaftor study providing the relevant results in the tabular form.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team