Low Glucose Enhances the Cytoprotective Effect of Metformin Against Doxorubicin Induced Cytotoxicity in Normal Cells

Review Data

The study is carefully performed and contributes data to therapeutic strategies for the treatment of cancer. However, there are issues that should be addressed.

Minor Essential Revisions

1) Please, rewrite the abstract introduction:

 - doxorubicin and toxicity

- metformin is a hypoglycemic agent and has a protective effect

2) In Abstract: To test the hypothesis that the anti-diabetic drug, metformin may protect normal cells during chemotherapy treatment with liposomal doxorubicin.

3) In Keywords add cancer

4) FDA - meaning

5) Please, add more current references.

Author Info

Fathima S. Ameer Xiaomin Zhang Gohar Azhar Yingni Che Jeanne Y. Wei

Corresponding Author

Jeanne Y. Wei
Department of Geriatrics, Donald W. Reynolds, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Article Info

Article Type

Research Article

Publication history

Received: Wed 24, Jun 2020
Accepted: Sat 18, Jul 2020
Published: Sat 08, Aug 2020

Copyright

© 2023 Jeanne Y. Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JDMC.2020.01.04