Single Nucleotide Polymorphisms in Four Genes Associated with Survival Outcome for Patients with Head and Neck Squamous Cell Carcinoma

Review Data

Purpose and Significance of Study: This study aimed to use a bioinformatics pipeline to explore the underlying mechanisms and identify genetic mutations that can be utilized to prognosticate individuals with head and neck squamous cell carcinoma (HNSCC). The results from this study may contribute to the evaluation of prognosis and development of future individualized HNSCC treatment.

Fit with Scope of Journal: The manuscript is of very high interest for the journal Clinical Oncology and Cancer Biology.

There are some minor errors in the manuscript (already corrected in the galley proof, except the highlighted one, which requires the author’s attention), which are listed below –

 

The common ones are –

·       Some abbreviations have been used without citing the full forms, e.g., HPV, PPI, GO, KEGG and GEPIA.

·       Omission of “,”, e.g., after “annually” in the 2^nd sentence of the 1^st paragraph of the Introduction, after “poor” in the 7^th sentence of the same paragraph, and so on.

·       Omission of articles, e.g., “the” before “identification” in the 6^th sentence of the 3^rd paragraph of the Introduction, before “PPI” in the 3^rd sentence of the last paragraph of the Introduction, and so on.

·       “Anticancer” and “antitumor” must be written without hyphens.

·       “P-value” and “cyclin-dependent” must be hyphenated.

 

The others are –

In the Abstract –

  Under Results –

·       In the 1^st sentence, “tumor” and “mutation” must be in plural.

In the Introduction –

  In the 1^st paragraph –

·       In the last sentence, “,” before “early” must be replaced with “by”.

  In the 2^nd paragraph –

·       In the 1^st sentence, “have” must be replaced with “has”.

·       In the last sentence, “may” must be replaced with “might”.

  In the 3^rd paragraph –

·       In the 2^nd sentence, “,” after “et al.” must be removed.

In the Materials and Methods –

  Under Construction of PPI network and analysis of mutation and expression –

·       In the 1^st sentence, “for” at the start must be replaced with “to”.

·       In the 4^th sentence, “for the purpose of elucidating” must be replaced with “to elucidate”.

  Under Association of selected mutant genes with HNSCC survival –

·       In the 1^st sentence, “tumor” must be in plural.

·       In the 2^nd sentence, “was” must be replaced with “were”.

·       In the last sentence, “which” must be replaced with “that”.

  Under GSEA analysis of the mutant genes –

·       In the last sentence, “phenotype” must be in plural.

  Under Drug Sensitivity of the mutant genes –

·       The 2^nd sentence “GSCALite contains…integrated into GSCALite” is incorrectly constructed, making it hard to read or understand. Hence, it must be re-written.

In the Discussion –

  In the 3^rd paragraph –

·       In the 1^st sentence, “analysis” must be replaced with “analyses”, and “indicate” must be replaced with “indicated”.

·       In the 6^th sentence, “,” before “Kim et al.” must be replaced with “.”, “,” before “the result” must be replaced with “;”, and “consisted” must be replaced with “consistent”.

  In the 4^th paragraph –

·       In the 3^rd sentence, “enrich” must be replaced with “enriched”.

  In the last paragraph –

·       In the 1^st sentence, “were” must be replaced with “was”.

·       In the 6^th sentence, “through” must be replaced with “by”, and “promotion of” must be replaced with “promoting”.

·       In the last sentence, “in” before “the therapy” must be replaced with “for”.

Author Info

Chang Liu Jing Lin Mi Meng Xu Ren Sheng Wang

Corresponding Author

Ren Sheng Wang
Department of Oncology Clinical Medical Research Center, Guangxi Medical University, Nanning, P.R. China

Article Info

Article Type

Research Article

Publication history

Received: Mon 04, May 2020
Accepted: Wed 20, May 2020
Published: Thu 28, May 2020

Copyright

© 2023 Ren Sheng Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COCB.2020.01.04