A Challenging Surgical and Reconstructive Approach to Locally Advanced Squamous Perineal Carcinoma: A Case Report and Literature Review

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments: The Discussion illustrates the surgical treatment and subsequent adjuvant immunotherapy in a 67-year-old patient who was diagnosed with perineal squamous cell carcinoma. It further highlights the rarity of the tumor, providing relevant literature. This concludes by stating that ideal diagnostic work-up, optimal treatment strategies, and prognosis are not well determined due to the rare occurrence of squamous cell CUP located in the male pelvis. Lastly, it suggests a treatment regimen for control of the symptoms for the localized tumors.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very Good

Writing style

Q: Is it clear and understandable?

A: Good

Comments: There are few errors found in the manuscript which are as follows. The highlighted sentence must be checked by the author.

·       In Abstract, 5^th paragraph, 2^nd sentence, “Later he received adjuvant treatment with immunotherapy (Cemiplimab) because was not subsidiary to treatment with platinum for renal failure” and under Surgical Procedure,  last paragraph, “The patient received three cycles of adjuvant treatment with immunotherapy (Cemiplimab 350 mg every 21 days), because was not subsidiary to treatment with platinum for renal failure” are not clear and need to be rephrased.

·       In Abstract, 2^nd paragraph, 1^st sentence, “67-year-old male patient who consults for urinary discomfort associated with perineal abscess” must be written as “A 67-year old male patient consulted for urinary discomfort associated with perineal abscess”. In last paragraph, “The patient died 9 after nine months of follow-up due to pulmonary and abdominal metastatic spread” must be written as “The patient died after nine months of follow-up due to pulmonary and abdominal metastatic spread”.

·       In Surgical Procedure, 7^th paragraph, 4^th sentence, “I presented a superficial dehiscence of the skin” must be “he presented with a superficial dehiscence of the skin”.

Further comments on the paper

Comments: The case presents a 67-year-old male patient with urinary discomfort associated with perineal abscess. On investigation, patient was diagnosed with perineal carcinoma of unknown origin. This report further describes the surgical procedure and the medication for the treatment of carcinoma.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Thanks,
Science Repository Team