The Role of Margin Status on Local Recurrence in Microinvasive Ductal Carcinoma of the Breast

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Author Info

Sara Grendele Alice Pellegrini Marica Melina Andrea Lippi Margherita Serra Mario Taffurelli Simone Zanotti

Corresponding Author

Sara Grendele
Breast Surgery, Department of Oncology and Hematological Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Italy

A B S T R A C T

Microinvasive ductal carcinoma (MIDC) is an infrequent disease that accounts for about 1% of all breast cancer cases. Controversy on the management is related to the limited information available regarding lymph node involvement, recurrence rate and prognosis of the disease. In this retrospective single-center study, we included all patients diagnosed with MIDC at S. Orsola Malpighi Hospital in Bologna from 2011 to 2020. Demographic and clinicopathologic characteristics were collected and analysed. Furthermore, we analysed the factors related to local recurrence using univariate and multivariate analyses. We identified 57 patients diagnosed with MIDC. The median age at diagnosis was 56. Nuclear grade of the invasive foci was high in 44% of the patients. Estrogen receptors were found to be positive in 40% of patients, HER2 was overexpressed in 35% and 40% of patients had a high proliferation rate. Margin status was negative in 72% of the patients while close in 16 patients. 26 patients received breast conserving surgery (BCS) and 31 underwent mastectomy. Nodal staging with sentinel lymph node biopsy was performed in 82% of cases. In 96% were found negative sentinel lymph node. 92% of patients receiving BCS were treated with combined radiotherapy. 32% were treated with adjuvant endocrine therapy and 28% were given adjuvant chemotherapy. At a median follow-up of 42 months, we had no axillary recurrence, but 3 patients (5%) had local recurrence. In the multivariate analysis close margins are associated with a 16% increase in local recurrence. Results from this study show that sentinel lymph node biopsy could not be useful in MIDC according to the low risk of lymph node metastasis. The rate of local recurrence was 5% and our findings suggested a possible role of margin status in the development of local recurrence.

Article Info

Article Type

Research Article

Publication history

Received: Mon 14, Jun 2021
Accepted: Wed 30, Jun 2021
Published: Wed 21, Jul 2021

Copyright

© 2023 Sara Grendele. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.SCR.2021.07.06