Erythroderma as a Paraneoplastic Cutaneous Disorder in Mantle Cell Lymphoma: A Case Report and Literature Review of Molecular Insights into Physiopathology

Erythroderma as a Paraneoplastic Cutaneous Disorder in Mantle Cell Lymphoma: A Case Report and Literature Review of Molecular Insights into Physiopathology

Author Info

Corresponding Author
Nayra Avina Padilla
Hospital General Regional No. 1, Cd. Obregón, Sonora México. Centro Medico del Noroeste, Unidad Médica de Alta especialidad (UMAE), Mexico

A B S T R A C T

Mantle Cell Lymphoma (MCL) is a lymphohematopoietic cancer of follicular origin and diffuse growth. It is a rare small B-cell lymphoma, with an incidence of 7-10% of all non-Hodgkin lymphomas, affecting adults (55-60 years), of which 80% are typically male. According to the World Health Organization guidelines, the diagnosis of MCL should be established based on morphological examination and immunophenotyping with detection of cyclin D1 resulting from the chromosomal translocation t(11;14)(q13;q32) of the CCND1 gene or SOX11 protein overexpression. Herein we present an infrequent clinical case of a female patient with MCL who presented erythroderma as a paraneoplastic cutaneous disorder. Moreover, we delved into the molecular insights of immune B-cell lymphocytic affections in this communication.

Article Info

Article Type
Case Report and Review of the Literature
Publication history
Received: Tue 26, Apr 2022
Accepted: Thu 12, May 2022
Published: Fri 27, May 2022
Copyright
© 2021 Nayra Avina Padilla. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.IJCST.2022.02.01