Human Gut Flora
Corresponding AuthorAbhijit Powar
Medical Director and Chief Consultant Sarasvati Surgical Hospital Ichalkaranji( Kolhapur), India
A B S T R A C T
Background: The intestinal microflora is a complex ecosystem. An improved understanding of this hidden organ will reveal secrets that are relevant to human health and to several infectious, inflammatory and neoplastic disease processes. Given the ability of the immune response to rapidly counter infectious agents, it is striking that such a large density of microbes can exist in a state of synergy within the human host. Objective: The relevance and effect of resident bacteria on a host’s physiology and pathology are extremely diverse. An ever-increasing body of evidence implicates the GI microbiota in defining states of health & disease. Materials and Methods: We review the literature in adult and pediatric GI microbiome studies, the emerging links between microbial community structure, function, infection and disease, and the approaches to manipulate this crucial ecosystem to improve host health. Conclusions: Manipulation of the flora is becoming a realistic therapeutic and prophylactic strategy for many infectious, inflammatory and even neoplastic diseases within the gut. Based on the influence of prenatal and early postnatal microbial exposures on the developing immune response to gut microbiome, aberrations in adulthood associated with chronic inflammatory diseases, have revealed the complexity of our dynamic relationship with microbes.
Article TypeReview Article
Publication historyReceived: Wed 01, Jan 2020
Accepted: Fri 17, Jan 2020
Published: Tue 28, Jan 2020
Copyright© 2019 Abhijit Powar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.