The use of Botulinum Toxin in digital reconstruction of patients affected by Raynaud?s phenomenon

Author Info

Francesco Segreto Giovanni F Marangi Mario Alessandri-Bonetti Paolo Persichetti Vincenzo Cerbone

Corresponding Author

Giovanni F Marangi
Department of Plastic, Reconstructive and Aesthetic Surgery, “Campus Bio-Medico di Roma” University, Rome, Italy

A B S T R A C T

Background: Surgical reconstruction in patients affected by Raynaud’s phenomenon is a challenging procedure due to the vascular impairment, which prevents flap survival and secondary healing. Botulinum Neurotoxin-A showed vasodilatatory and angiogenic properties in animal studies, increasing blood flow in flap surgery. Case presentation: We report an off-label application of Botulinum Neurotoxin-A used for digital reconstruction in a patient affected by Reynaud’s phenomenon, in order to enhance flap survival and avoid digital amputation. Complete flap survival and symptomatic relief were achieved. Conclusions: This new approach may be extremely valuable when performing flap reconstruction in patients affected by RP, allowing for increased vascular safety as well as symptomatic improvement.

Article Info

Article Type

Case Report

Publication history

Received: Fri 16, Nov 2018
Accepted: Wed 28, Nov 2018
Published: Thu 20, Dec 2018

Copyright

© 2023 Giovanni F Marangi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.SCR.2018.03.023